Lisbon, Portugal - May 8 - 9, 2024


Thursday, May 4  | 15:20 – 15:40 pm

Telomeres and Biology of Aging

by Fabrizio d’Adda di Fagagna, PhD, Principal Investigator of Institute of Molecular Genetics (CNR), Pavia, Italy

Cell aging, also known as cellular senescence, was first demonstrated to be caused by telomere shortening and dysfunction. It is now well stablished that short and damaged telomeres are associated, often in a causative manner, with several age-related severe human diseases and aging itself. Nevertheless, so far we lacked the means to blunt the consequences of telomere dysfunction. We will discuss an innovative approach, presently in preclinical development, effective in a variety of animal models of accelerated aging and age-related disorders.

Thursday, May 4  | 17:10 – 17:30 pm

Fundamental Biomedical Research, Interdisciplinary and Longevity

by Cláudia Cavadas, Head of the Neuroendocrinology and Aging Group, Center for Neuroscience and Cell Biology of the University of Coimbra (CNC-UC); Professor of Pharmacology, Faculty of Pharmacy, Univ. Coimbra, Portugal

Friday, May 5  | 09:00 – 9:20 am

Prevention is the best therapy – The role of genetics

by Dr. Stefanie Wendel, Medical Manager of Prevention Division, CeGaT GmbH, Tübingen, Germany

Friday, May 5  | 9:40 – 10:00 am

The Use of Autologous Stem Cells in Regenerative Medicine. cGMP Stem Cell Banking

by Elena Rusyn, PhD, Chief Scientific Officer at American Cell Technology, Sunrise, Florida, USA

Stem cell therapy and research are offering new benefits to patients with limited treatment options offered through traditional methods. Regenerative medicine centers all over the world are working on different cell types to meet this need. Selecting a suitable cell type and tissue source for human clinical applications in the field of regenerative and anti-aging medicine is an important challenge. The ethics issues around the embryonic cells tumor formation, and rejection make it a less interesting candidate for clinical applications. Other sources of stem cells are induced pluripotent stem cells (iPS cells). There are still several issues on the processes adopted to produce the iPS cells from adult stem cells for therapeutic purposes that limit their utility. In sharp contrast, progress with adult stem cells has been impressive. Since mesenchymal stem cells (MSCs) can be easily harvested from the adipose tissue and can also be cultured and expanded in vitro they have become a good target for tissue regeneration. They have a broader differentiation capacity than previously thought, since they give rise to cell types of multiple tissues. The continuing debate here is about what cells, allogeneic or autologous, are the safer option for clinical applications. Over the past few decades, allogeneic stem cells have been recognized as good sources of stem cells for transplantation. However, despite several advantages and the high therapeutic potential of this approach, there are important concerns related to long-term side effects, regulatory-compliance, immunogenic response and infection incidence rates. In contrast, cell-based therapies based on autologous cells derived from adipose tissue offer exceptional high safety profile and clinical outcomes.

Thursday, May 5  | 11:50 – 12:10 am

Big data and the science of ageing

by João Pedro Magalhães, Principal Investigator, Genomics of Ageing and Rejuvenation Lab, Birmingham, UK

Age-related conditions are the leading causes of death and healthcare costs. Retarding the ageing process would have enormous medical and financial benefits. A large number of genes and drugs extending lifespan in model organisms already exist, yet given long validation times, only a small fraction of them can be explored for humans clinical applications. Therefore, prioritizing drugs and gene targets is imperative. In this talk, I will present big data and machine learning approaches for predicting longevity genes and compounds, which we validated experimentally. I will also present integrative, multi-dimensional approaches that provide insights into longevity pathways and their role in age-related diseases. Overall, our data-driven approaches allow us to identify and prioritize further compounds with potential healthy longevity properties.