At the Longevity Med Summit Guido Kroemer will perform the following lecture:
Autophagy enhancement as an antiaging strategy Autophagy acts as a cytoplasmic rejuvenation mechanisms, implying that its enhancement has a marked geroprotective effect. Our group focuses on the identification of endogenous metabolites that stimulate autophagy, as well as on the identification of extracellular autophagy-inhibitory proteins (or ‘checkpoints’) the neutralization of which unblocks autophagy. Irrespective of their precise mode of action, autophagy enhancers have cytoprotective, anti-inflammatory and antifibrotic effects that combat aging and age-related pathologies. This applies to avariety of highly prevalent cardiovascular, neurodegenerative, malignant and metabolic diseases.
Guido Kroemer is currently Professor at the Faculty of Medicine of the University of Paris Descartes, Director of the research team “Metabolism, Cancer and Immunity” of the French Medical Research Council (INSERM), Director of the Metabolism and Cell Biology plataforms of the Gustave Roussy Comprehensive Center, Deputy Director of the Cordeliers Research Center, and Hospital Practitioner at the Hôpital Européen George Pompidou, Paris, France. Guido Kroemer is also a Foreign Adjunct Professor at the Karolinska Institute, Stockholm, Sweden.
Guido Kroemer has made important contributions to medical research through his groundbreaking work in the fields of cell biology and cancer research. He is best known for the discovery that the permeabilization of mitochondrial membranes constitutes a decisive step in programmed cell death. Kroemer has explored the fine mechanisms of mitochondrial cell death control, the molecular pathways that explain the inhibition of cell death in cancer cells, upstream of or at the level of mitochondria, and the mechanisms that make cancer cell death immunogenic. His work has had far reaching implications for the comprehension, detection and therapeutic manipulation of cellular demise.
Guido Kroemer´s contributions have been recognized with numerous awards, including the Monika Kutzner Prize of the Berlin-Brandenburg Academy of Sciences (1998), the Gallet & Breton Prize of the French Academy of Medicine (1999), the Descartes Prize of the European Union (2006), the Carus Medal of the German Academy of Sciences (2007), the Grand Prix Mergier-Bourdeix of the French Academy of Sciences (2007), the Lucien Dautrebande Prize of the Belgian Royal Academy of Medicine (2009) , the Duquesne Prize of the French National League against Cancer (2010), the “Coup d´Elan” Prize of the Bettencourt-Schueller Foundation (2011) , the Léopold Griffuel Prize of the French Association for Cancer Research (2012), an Advanced Investigator Award from the European Research Council (2013), and the Mitjavile Prize of the French Academy of Medicine (2014) , the Galien Prize for Pharmacological Research (2015), the Grand Priz Claude Bernard of the City of Paris (2016), the Brupbacher Prize for Cancer Research (2017), the ADPS Longevity Research Award (2018), the Baillet-Latour Health Prize (2018) and the international Lombardia è Ricerca Prize (2019) among others.