New Insights and Approaches to Skeletal Muscle Aging

Nathan K. LeBrasseur

Director, Robert and Arlene Kogod Center on Aging, Mayo Clinic, USA

Dr. Nathan LeBrasseur, PT, PhD, is a Professor in the Department of Physical Medicine and Rehabilitation and has a joint appointment in the Department of Physiology and Biomedical Engineering at Mayo Clinic. Dr. LeBrasseur is the Director of the Robert and Arlene Kogod Center on Aging, the Co-Director of the Paul F. Glenn Center for Biology of Aging Research, and Scientific Director of the Office of Translation to Practice at Mayo Clinic. He is the recent chair of the NIH Cellular Mechanisms in Aging and Development Study Section. Dr. LeBrasseur’s research team conducts translational “bench-to-bedside” research on strategies to improve physical function, metabolism, and resilience in the face of aging and disease. His latest work has centered on cellular senescence, a fundamental mechanism of aging, and interventions to counter this process to extend healthspan. Dr. LeBrasseur has received the Glenn Award for Research in Biological Mechanisms of Aging, the Nathan W. Shock Award Lecture from the National Institute on Aging, and the Vincent Cristofalo Rising Star Award in Aging Research from the American Federation for Aging Research. He is a Fellow of the Gerontological Society of America.

Nathan K. LeBrasseur, Mayo Clinic

New Insights and Approaches to Skeletal Muscle Aging

Skeletal muscle is the largest organ by mass in humans and plays a central role in movement, metabolism, and resilience to stress. From the fourth to ninth decade of life, humans lose approximately 30% of their skeletal muscle, which has profound consequences for health, independence, and quality of life. Despite its significance, there are no currently approved therapies. This seminar will highlight these aspects of skeletal muscle aging and provide new insights from studies in preclinical models and humans into the underlying biology and promising interventions, with a focus on cellular senescence.

At the next 2024 Longevity Med Summit Dr. Nathan will discuss how aging affects the health and function of cells that compose skeletal muscle, and how these changes result in skeletal muscle loss, fibrosis and fat infiltration at advanced ages. By developing interventions to counter the biology of aging, including cellular senescence, Dr. LeBrasseur and colleagues intend to optimize skeletal muscle strength and physical function and, in turn, prevent disability and frailty in older adults.