Bosch graduated from the University of Munich. His work on the non-senescent animal model Hydra contributed to the development of new paradigms in a range of topics in evolutionary developmental biology. His research uncovered that animal hosts are living closely intertwined with their microbiome in symbiotic communities forming a metaorganism. His lab also demonstrated that environmental factors such as an altered microbiome can disrupt the stem cell system and tissue homeostasis, triggering tumor formation. Bosch has decoded the longevity gene and transcription factor FoxO as one of the evolutionarily conserved genes controlling stem cell aging and immune senescence.