Specialist in Microbiome and Integrative Functional Medicine, Portugal
There is an intricate relationship between oestrogen-related conditions and gut microbiota. Oestrogens undergo a complex detoxification process in the body, passing through three phases in the liver, intestines, and bladder. However, a critical aspect of this process involves glucuronidation, a pathway that renders oestrogens more water-soluble for excretion but can be disrupted by gut microbial enzymes. The objective is to highlight the pivotal role of glucuronidation in oestrogen metabolism and its potential impact on sex hormone dysregulation, liver congestion, weight regulation, and inflammation. The importance of considering oestrogen excretion alongside metabolism must be emphasized, as overlooking this aspect may lead to unanswered questions in patient management. By examining the interplay between oestrogen metabolism and gut microbiota, healthcare practitioners can gain valuable insights into addressing oestrogen-related conditions effectively.
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