EDSON LUIZ PERACCHI* – LIANE ATHAYDE BERINGHS-BUENO *,** – MARIA DO PERPÉTUO SOCORRO AFONSO TROVISCO MOURA**** – PAULO ROBERTO DA SILVA MOURA JÚNIOR*,***

*ABEMAE – Academia Brasileira de Medicina do Ativo Envelhecimento

** Instituto Assaly de Medicina Personalizada

*** Clínica Caldas

– SERIES OF CASES REPORT

Introduction:

Parkinson’s disease (PD) is a major cause of death and disability. It affects ~2% of the population above the age of 65 and its prevalence increases dramatically as the population ages. PD is characterized by dopaminergic neuronal death in the substantia nigra, and it exhibits aberrant protein aggregation and mitochondrial dysfunction. Mitochondrial damage is a key feature in PD. Boosting both mitochondrial biogenesis and function will allow alleviation of PD-related symptoms.

Nicotinamide Adenine Dinucleotide (NADH) plays a vital role in cell functionality and dopaminergic neuronal replenishment, whereas NADH depletion has been associated with the onset of neurodegenerative diseases such as PD.

Boosting neuronal NADH levels allows improvement of mitochondrial function and could slow PD progression.

Methods: Case Series Reports Results:

Case 1: XX year-old male, PD two years prior to medical appointment, used PD medication with no symptoms relief. Patient received 10 mg of intramuscular (IM) NADH twice a week, total of 10 doses, and 10 mg of NADH oral tablets daily for 60 days. After the second week of treatment, tremors decreased, and improvement of cognitive performance and depression symptoms have also observed.

Case 2: 56 year-old female, PD 11 years prior to medical appointment, used PD medications with continuous increase of symptoms. Patient received 100 mg of NADH subcutaneous pellets. Tremors and stiffness decreased progressively, and improvement in sleep, speech and depression symptoms have also been observed.

Case 3: 54 year-old female, PD four prior to medical appointment, never used PD medication. Patient received 10 mg of intramuscular (IM) NADH twice a week, total of 10 doses, and 10 mg of NADH oral tablets daily, for 60 days. Tremors decreased, and improvement of muscular pain and stiffness were also observed.