As an internist working in longevity medicine I am frequently confronted with meaningful implementation of preventive (drug) strategies. IN my presentation I would like to report about experiences with Gingko Biloba (GB) extract. The incidence of neurodegenerative diseases, cardiovascular disease (CVD), hypertension, insulin resistance, cancer, and other aging cell  processes like mitochndrial dysfunction increases with aging. Ginkgo biloba (GB) is associated with several health benefits, including memory and cognitive improvement, in Alzheimer’s disease (AD), Parkinson’s disease (PD), and cancer. Its antiapoptotic, antioxidant, and anti-inflammatory actions have (preventive) effects on cognition and other conditions associated with aging-related processes, such as insulin resistance, hypertension, and cardiovascular conditions.

I will summarize the current scientific evidence of age-related preventive effects of GB and report the implementation in my clinical practice emphasizing the preventive long- term effects für patients. The summary of the respective studies showed that GB can improve memory, cognition, memory scores, psychopathology, and the quality of life of patients. Moreover, it can improve cerebral blood flow supply, executive function, attention/concentration, non-verbal memory, and mood, and decrease stress, fasting serum glucose, glycated hemoglobin, insulin levels, body mass index, waist circumference, biomarkers of oxidative stress, the stability and progression of atherosclerotic plaques, and inflammation. Therefore, GB has an enormous potential in longevity medicine and is able to provide clinical meaningful benefits in the prevention and treatment of aging-related conditions.