Aging is a complex multifactorial process of molecular and cellular decline that affects tissue function over time, rendering organism’s frail and susceptible to disease and death. As human life expectancy is prolonged, age-related diseases are thriving. Molecular integrity of the genome, telomere length, epigenetic landscape stability, and protein homeostasis are all features linked to “youthful” states. These molecular hallmarks underlie cellular functions associated with aging like mitochondrial fitness, nutrient sensing, efficient intercellular communication, stem cell renewal, and improved regenerative capacity in tissues. Various research and clinical trials have shown that HBOT can positively impact the aging process at a cellular level. By delivering oxygen at higher concentrations and pressures, HBOT stimulates the production of new blood vessels, reduces inflammation, and activates vital cellular repair mechanisms. Senolytic drugs have been designed to clear senescent cells, but they haven’t been proven to be effective in human clinical studies. “The only therapy proven to be effective in a clinical setting is the hyperoxic-hypoxic paradox, one the protocol using in HBOT. HBOT supports angiogenesis and blood-brain-barrier integrity restoration – two facts that are incredibly important when it comes to stabilizing and reversing neurological decline, angiogenesis is crucial because as we age, our blood vessels experience atherosclerosis and begin to narrow and there’s not a sufficient oxygen supply to the tissue and it cannot regenerate and repair itself without sufficient oxygen, the tissue vascularization is important part of regeneration process.