SUPPLEMENTS

Background: Selenium and coenzyme Q10 are both important for optimal function of all living cells. It is known that a decreased level of either – or both – substances increases the risk for diseased patients. It is also known that the ageing process in the cardiovascular system results also in increased inflammation and oxidative stress. We wanted to evaluate if supplementation with selenium and CoQ10 could influence the ageing process of the cardiovascular system, and also mortality. 

Methods: 443 elderly community living persons were included. On top of their usual medication, if any, they received selenium 200 micrograms/day, and coenzyme Q10 200 mg/day during 4 years. The follow-up time is now 12 years. Evaluations of cardiovascular mortality has been performed. As the ageing process is complex, we wanted to cover different aspects of the process. Therefore, we performed sub-analyzes involving endothelial dysfunction, inflammation, fibrosis, and apoptosis and metabolic profiles. We also evaluated expression of microRNA and different biomarkers involved in the ageing process. Finally, we analysed the telomere length of the chromosomes. 

Results: Significant reduced cardiovascular mortality could be demonstrated in the active treatment group after 5 years, 10 years and 12 years. Highly significant differences in biomarkers for inflammation, fibrosis and apoptosis could be demonstrated. Significant differences in expression of microRNA, in metabolic profiles, but also in the length of telomeres could also be reported, and finally also regarding the “ageing” biomarkers. 

Conclusion: The supplementation with selenium and coenzyme Q10 results in significantly reduced mortality that can be seen also after 12 years. This is the result of a complex mechanism in the body, where the ageing process of the cardiovascular system is central. All pointing in the direction, that in those who are low in selenium and coenzyme Q10, supplementation could slow down the accelerated ageing of the cardiovascular system that results. Finally, we could demonstrate reduced mortality also after 12 years as a result of the supplementation with selenium and coenzyme Q10.